MapGuide 2.0 was Released on Thursday, with the main feature being:
the integration of Fusion; a flexible, extensible templating system that provides the ability to separate application presentation from its functional components
More information on Fusion is available from DM Solutions. Fusion uses OpenLayers as its mapping layer, and the recent addition of the MapGuide layer to OpenLayers trunk was as a result of the efforts put forth by DM Solutions to help contribute back improvements made to OpenLayers for its use within Fusion.
You can see examples of Fusion in action on the MapGuide Beta site.
Congrats to the MapGuide team on their success in using OpenLayers to build a great looking frontend for MapGuide maps!